TLR4 activated by fucoidan induces ROS-associated ERS by activating the PERK–ATF4–CHOP pathway [28] and promotes caspase-3 activation through the TLR4–ERS–CHOP pathway, resulting in apoptosis in lung cancer cells (Figure 2; Table 1) [29]. The gene discussed is DDIT3; the disease is lung carcinoma.