GBM sEVs are also enriched in long non-coding RNA activated by transforming growth factor (TGF)-β (lncRNA-ATB), which is transferred to astrocytes, where it suppresses miR204-3p to increase Glial fibrillary acidic protein (GFAP) expression, leading to reactive astrocyte activation and enhanced glioma invasiveness [166]. Here, GFAP is linked to central nervous system cancer.