APOA2 and familial pancreatic carcinoma: The two aberrant processing patterns of apoA2 isoforms are also observed in individuals at high risk for developing PDAC, and analyses of these isoforms enables an efficient detection of IPMN, which is considered a precancerous lesion, as well as other pancreatic conditions (e.g., chronic pancreatitis) that predispose patients to pancreatic cancer [108,109].