AKT1 and neoplasm: As a potential link with reduced p-Akt/Ser473 levels, Western blot analysis showed significantly increased p21waf1 protein expression in tumor cell cultures treated with R+mEHT compared to the controls (p = 0.013) and the Kruskal–Wallis test showed a strong significance among the 4 groups (p = 0.0014) (Figure 4C,D).