In the Panc1 cell line, high-fever range hyperthermia has been described to reduce (TGF-β1-induced) tumor migration, and epithelial-mesenchymal transition (EMT) driven invasion both in genetically unmanipulated—using 43 °C for 60 min, [47] and in gemcitabine resistant Panc1 pancreas ductal adenocarcinoma cells—at 42 °C for 60 min [46]. This evidence concerns the gene TGFB1 and neoplasm.