Indeed, localized radiotherapy can enhance tumor antigenicity, adjuvanticity, and immunogenicity through the increase of MHC (Major Histocompatibility Complex) class-I expression, the induction of cGas (cyclic GMP–AMP synthase)/ STING (stimulator of interferon genes)/ IFN-I (type-I interferon) pathways, and the induction of ICD. The gene discussed is STING1; the disease is neoplasm.