The authors showed in mouse mammary carcinoma TS/A that high single or multiple doses of radiations (> 12–18Gy) induced Trex1, which in turn degrades cytoplasmic dsDNA and prevents the activation of the cGAS/STING/IFN I pathway, thus impairing the ability of radiotherapy to stimulate the immune system. This evidence concerns the gene TREX1 and breast carcinoma.