Our group reported in two mouse models of colorectal cancer that high levels of IFNγ secretion, PD-L1 expression, and PD-1+ memory CD8 T cells in the tumor were induced upon Folfox (5-FU plus Oxaliplatin) immunogenic chemotherapy treatment [34], leading to the conversion of ‘cold’ tumor into ‘hot’ tumors [28]. This evidence concerns the gene CD274 and neoplasm.