Gal-3 expression in biliary epithelial cells is increased during PBC, and since these cells play an active role in PBC pathogenesis, the role of Gal-3 in NLRP3 inflammasome activation in cholangiocytes in PBC development needs to be elucidated, but also the role of this axis in the development of intrahepatic cholangiocarcinoma. This evidence concerns the gene NLRP3 and primary biliary cholangitis.