LGALS3 and primary biliary cholangitis: Gal-3 expression in biliary epithelial cells is increased during PBC, and since these cells play an active role in PBC pathogenesis, the role of Gal-3 in NLRP3 inflammasome activation in cholangiocytes in PBC development needs to be elucidated, but also the role of this axis in the development of intrahepatic cholangiocarcinoma.