It is clear that inhibition of galectin-3 signaling and inflammasome activation may be a potential target for the treatment of primary biliary cholangitis, however further studies are needed to explore the balance between beneficial and harmful effects of Gal-3 in different phases of PBC pathogenesis and different types of cells that play a roles in PBC pathogenesis. Here, LGALS3 is linked to primary biliary cholangitis.