IL6R and metastatic neoplasm: In contrast, the IL1RA levels for patients with metastatic disease (n = 6, median 802 pg/mL, range 335–1607 pg/mL) did not differ significantly from those of patients without metastases (n = 91, median 684 pg/mL, range 281–2711 pg/mL), and IL1RA also did not differ between patients with non-metastatic disease and those with metastatic disease or between those with small versus large tumors without metastases.