The aim of the present study was to characterize the heterogeneity of the cytokine-driven acute phase reaction (i.e., the biological context of CRP) in patients with renal cell carcinoma by investigating an extended pre-therapy acute phase cytokine profile that includes seven IL6 family members, IL1 subfamily members (IL33Rα and IL1β/IL1RA), and TNFα. Here, IL1B is linked to hereditary clear cell renal cell carcinoma.