SOX2 and central nervous system cancer: Additionally, a prolonged treatment with TMZ was proved to induce dormancy in glioma cell lines, which acquire characteristics of stem cells through the expression of dormancy markers, such as the insulin-like growth factor binding protein 5 (IGFBP5), the ephrin type-A receptor 5 (EphA5), and the histone cluster 1 H2b family member K (H2BK), and stem cell markers, such as the octamer binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and krüppel like factor 4 (KLF4) [196].