Zhang et al. reported that HAMLET (a decalcified a-lactalbumin and oleic acid complex) induces the activation of p62, leading to cell death by apoptosis in the U87 glioma line by activation of caspase-8 [153]; those authors suggested that ubiquitinated caspase-8 could activate the autophagosome by binding p62 [153,154]. The gene discussed is CASP8; the disease is central nervous system cancer.