BNIP3 and neoplasm: In addition, it has been reported that autophagy activation under hypoxia is related to transcriptional changes in genes, such as BNIP3, BNIP3L, PIK3C3, and ATG9A. Rahim et al. reported that inhibiting ATG9A decreased autophagy induction by hypoxia in intracranial glioma tumors, an effect linked to a significant decrease in tumor volume and an increase in mouse survival [173].