ATF4 and neoplasm: Under stress conditions, solid tumors, such as glioblastoma, exhibit resistance to cell death by inducing autophagy in cells detached from the primary tumor through PERK and the subsequent activation of the activating transcription factor 4 (ATF4), which induces the expression of autophagic genes, including ATG5, ATG7, and ULK, and of the antioxidant enzyme hemoxygenase-1, preventing anoikis and favoring the survival and migration of tumor cells [188].