Tamrakar et al. demonstrated that a marked increase in the expression of p62, LC3, and Beclin-1 was related with radiation therapy in glioblastoma biopsy samples, whereas LC3 and p62 expression was associated with a poorer overall survival, and LC3 was associated with the methylation in the promoter of O6-methylyguanine-DNA methyltransferase (MGMT) and telomerase reverse transcriptase (TERT). The gene discussed is SQSTM1; the disease is glioblastoma.