For instance the EDEN birth cohort study, focusing on determining peri-natal factors that influence childhood health and social development, pointed out that a pre-natal exposure to PM10 (particles with diameter less than 10 μm) was linked to an increased in CD8+ T cell and a decreased in regulatory T cells in infants at birth, leading to a potential increase in the susceptibility of viral infection responses as well as atopy development in children [78]. Here, CD8A is linked to viral infectious disease.