Evidence suggests that CTD exerts cytotoxic effects on pancreatic cancer cells by JNK-dependent pathway, as CTD treatment suppressed pancreatic cancer cell proliferation via stimulating caspase-8 and caspase-9, upregulating expression level of Bad, Bid and Bak, while downregulating Bcl-2 [60]. The gene discussed is CASP8; the disease is familial pancreatic carcinoma.