CTD caused sensitization of pancreatic cancer cells towards radiotherapy by elevating DNA damage and suppressing DNA repair associated genes namely UBE2T, RM1, RPA1, XRCC1, GTF2HH5, RAD51B, RAD50, RAD51B, PRKDC, LIG1, FANC1, DMC1, POLD3 and FAAP100 through JNK, ERK, p38, PKC and NF-κB pathways [78]. Here, MAPK8 is linked to familial pancreatic carcinoma.