CUX1 and neoplasm: When stratified by a CUX1 IRS cut-off 8, patients with CUX1 IRS > 8 had a significantly reduced median recurrence-free survival (RFS) of 8 months, compared to patients whose tumours showed an CUX1 IRS < 8 (Figure 1C), indicating that CUX1 protein expression is able to stratify patients into two distinct tumour-biologically relevant subgroups.