ERα has also been reported to mediate estrogen-induced neutrophil migration in the uterus through ERα phosphorylation at serine 216 (Shindo et al., 2013), and ERα mediated the effect of estrogen on myeloid-derived suppressor cells, which are mostly granulocytic cells, in stimulating tumor development in mice model (Svoronos et al., 2017). The gene discussed is ESR1; the disease is neoplasm.