Complications of increased cardiac ACE2 include the development of fulminant myocarditis with increased COVID-19 viral load.2,57 It has also been noted there are increased serum levels of Ang II in COVID-19 patients, indicating potential down regulation of ACE2 as seen in SARS-CoV contributing to acute lung injury.57 As illustrated by South et al,52 there is paucity of data exploring the impact of ACEIs and ARBs on the ACE2-Ang-1-7-Mas receptor axis. This evidence concerns the gene AGT and COVID-19.