IL6 and Alzheimer disease: On the other hand, IL-6 showed a more robust increase (about threefold) in DEL with respect to the other two groups (18.0 ± 12.7 vs. 5.9 ± 4.0 vs. 6.3 ± 4.2 pg/ml, DEL vs. AD vs. CTRL, respectively, p < 0.001; Fig. 2b), and TNF-α failed to show any change (3.3 ± 2.2 vs. 3.3 ± 1.4 vs. 3.8 ± 1.7 pg/ml, DEL vs. AD vs. CTRL, respectively; Fig. 2c).