IL2RB and tropical spastic paraparesis: Hu-Mikβ1, which is a humanized monoclonal antibody against the β subunit shared by the IL-2 and IL-15 receptors (IL-2/IL-15Rβ; CD122), has been reported to inhibit abnormal T cell proliferation and HTLV-1-specific cellular immune responses by blocking IL-15 action in HAM/TSP patients (Azimi et al. 1999; Enose-Akahata et al. 2008).