Cows classified as SCH had less (P ≤ 0.04) mean concentrations of insulin and IGF-I compared with NORM cows (0.396 vs. 0.738 ppmol/L for insulin, SEM = 0.115; 35.9 vs. 57.9 ng/mL for IGF-I, SEM = 4.2, respectively), and such outcomes were also noted since the beginning of the experiment (Fig. 5). The gene discussed is IGF1; the disease is spindle cell hemangioma.