GLP‐1 improves insulin signal transduction in adipocytes by upregulating Akt phosphorylation and protein expression of cyclins A, D1 and E.92Moreover, the direct effect of GLP‐1 RAs on hepatocytes has been validated by in vitro study where exenatide activated genes involved in hepatic fatty acid oxidation and insulin sensitivity in hepatocytes isolated from rats with NASH,93 although conflicting data still exist in terms of the presence of GLP‐1 receptors on human hepatocytes.94 This evidence concerns the gene CCNA2 and metabolic dysfunction-associated steatohepatitis.