The effect of circadian‐timed bromocriptine to normalize VMH glucose sensing in insulin‐resistant animals may involve its action to restore the daily circadian peak in brain dopaminergic activity on striatal neurons as well as such documented effect on the SCN3 inasmuch as intracerebroventricular bromocriptine administration or direct SCN dopamine administration each ameliorate glucose intolerance and insulin resistance.3, 12. This evidence concerns the gene INS and Insulin resistance.