In insulin‐resistant states, both the presynaptic release of norepinephrine at the VMH and the postsynaptic response to norepinephrine on VMH neurons are elevated37, 38 and artificial induction of this hyper‐noradrenergic alteration in lean, insulin‐sensitive animals is sufficient to induce insulin resistance and glucose intolerance even in such animals on RC.9, 10, 39, 40, 41. The gene discussed is INS; the disease is Insulin resistance.