Circadian‐timed bromocriptine administration at the time of day of the daily peak in central dopaminergic activity in lean insulin‐sensitive animals and that is diminished in obese HFD‐fed animals reverses the effect of the HFD on the VMH GE and GI responses to hyperglycaemia and hypoglycaemia, respectively to mimic conditions in lean insulin‐sensitive animals. This evidence concerns the gene INS and Hypoglycemia.