Since bromocriptine reduces this increased VMH NE activity and normalizes both the aberrant GE and GI responses to hyperglycaemia and hypoglycaemia, respectively, leading to improved glucose tolerance and insulin sensitivity, the composite of these findings suggests that BC action to normalize elevated VMH NE activity participates in its effect to normalize VMH GE glucose sensing and ultimately reduce glucose intolerance and insulin resistance. This evidence concerns the gene INS and Insulin resistance.