INS and diabetes mellitus: Based on the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommendations, once the glycaemic control is insufficiently achieved by using other antihyperglycaemic agents, the intensification with insulin should be considered and should not be delayed.9, 10 Treatment with insulin has the advantage of being highly effective in reducing blood glucose levels as mono‐therapy or in combination with any other agents, especially in severe hyperglycaemia when blood glucose levels reach ≥300 mg/dL or HbA1c ≥ 10%.11