These studies described the epidemiology of Epstein-Barr virus (EBV), prevalence of EBV, human herpes virus 8 (HHV-8), and human immunodeficiency virus (HIV)-1 in B-cell non-Hodgkin lymphoma, age-specific patterns of Burkitt lymphoma (BL) cases, malaria, and risk of endemic Burkitt lymphoma (eBL) and factors associated with time to diagnosis of BL cases.The next-generation sequencing (NGS) to detect B-cell receptor (BCR) gene rearrangements in eBL, oral human herpes virus shedding kinetics, EBV viral load, and serology were investigated. This evidence concerns the gene BCR and Burkitt lymphoma.