Serum tumor marker detection is a non-invasive detection method for the diagnosis and screening of GC.16 In the present case-control study, we profiled the expression levels of 10 MMPs in serum samples from 66 GC and 34 NGD patients using antibody microarrays and found a panel of 5 MMPs (including MMP-3, -8, and -9 and TIMP-1 and -2) which could effectively identify GC and EGC with an AUC of 0.821 (95% CI: 0.733-0.909) and 0.749 (95% CI: 0.600-0.898), respectively. This evidence concerns the gene MMP3 and neoplasm.