Antibody microarray-based technology applied in the present study combines the specificity of ELISA and sensitivity of ECL with a high throughput array.17 A study by Choudhry et al. found six proteinases (MMP-1, -2, -8, -10, -12, and -13) with significant differential expression in the serum of the oral squamous cell carcinoma (OSCC) patients and healthy controls.18 Among them, the MMP-12 had the highest AUC of 0.836 (95% CI: 0.733-0.911) with a sensitivity and specificity of 80.0% and 78.9%, respectively. The gene discussed is MMP1; the disease is oral cavity squamous cell carcinoma.