Interestingly, AG-205 has been shown to disrupt the interaction between PGRMC1 and actin cytoskeleton-associated proteins; this could have a profound impact on cancer cell metastasis, and why it impaired the migratory capabilities in our study.30 Since AG-205 did not decrease PGRMC1 expression, while inducing potent anticancer effects, further analyses were conducted to ascertain that all these effects were due to PGRMC1. Here, PGRMC1 is linked to cancer.