Hereby, we show for the first time that, a complex network of IFN-γ, CEBPB (a transcription factor drives obesity through adipogenesis5,7,8), miR-520G, and p53-defects co-operatively regulate the expression of MYO18B mRNA which in turn reflects the poor survival of HCC patients (Fig. 7). Here, MYO18B is linked to obesity due to melanocortin 4 receptor deficiency.