In summary, our study identified a complex network of IFN-γ, CEBPB, C19MC miR-520G and p53-transcriptional incompetence as positive regulators of MYO18B mRNA expression and bFGF as negative regulator of MYO18B mRNA expression to reflect the survival outcome of HCC patients. This evidence concerns the gene TP53 and hepatocellular carcinoma.