Similar to the profile of DNMT3A mutations found in clonal hematopoiesis in healthy individuals, mutations observed in Tfh lymphoma patients do not accumulate in the DNMT3A methyltransferase domain, and hotspot R882(H) mutations are less frequent in AITL samples [29, 33, 38]. The gene discussed is DNMT3A; the disease is angioimmunoblastic T-cell lymphoma.