Interestingly, EBV+ B cells reportedly lose functional Ig due to destructive hypermutations in most AITL cases accompanied by EBV+ B cells [108], indicating that B-cell proliferation in these cases does not require B-cell receptor (BCR) signaling but rather is driven by a different pathway (Fig. 3). The gene discussed is BCR; the disease is angioimmunoblastic T-cell lymphoma.