In our study, EM patients showed higher values than healthy controls for nine parameters: the relative count of lymphocytes, relative and absolute counts of CD3 T cells, relative and absolute counts of CD8 suppressor cytotoxic T cells, relative and absolute counts of CD4 + TEMRA, absolute count of CD8 naïve T cells, and absolute count of CD19 switched memory B cells respectively. This evidence concerns the gene CD4 and erythema multiforme.