In the primary analysis of the data used in the present study, Ding et al.9 reported differential expression of genes annotated in immunological pathways in the age:tissue interaction analysis (B Cell Development, iCOS-iCOSL Signaling in T Helper cells, CD28 Signaling in T Helper Cells, Primary Immunodeficiency Signaling, Calcium-induced T Lymphocyte Apoptosis), including genes such as complement family genes, immune-cell surface antigens, chemokines, interleukin receptors, natural killer cells and extracellular matrix remodeling genes. The gene discussed is ICOS; the disease is inborn error of immunity.