A recent analysis of 1281 EO-PCa cases (≤ 60 years) identified 23 unique DNA repair genes associated with an increased predisposition or risk of aggressive PCa disease, and four genes (BRCA2, MSH2, ERCC2, and CHEK2_non1100del) were associated with more aggressive disease10. The gene discussed is ERCC2; the disease is posterior cortical atrophy.