However, in animals lacking NOD1 in the hematopoietic system, Chan et al.18 reported that after 18 weeks of HFD, the WT animals exhibited hyperinsulinemia, insulin resistance and a reduced capacity to decrease glucose overload, a situation that was significantly more benign in the hematopoietic NOD1 deficient mice. Here, NOD1 is linked to hyperinsulinism.