Moreover, reversion to CHD after 6 weeks of HFD shows a significant recovery in the liver steatosis of the NOD1 KO animals and almost complete absence of Oil-red O staining in the WT counterparts, which is in agreement with the failure of the establishment of the insulin-resistance phenotype in these 6 weeks of HFD regimen. The gene discussed is INS; the disease is digestive system neoplasm.