The key sterol hydrolases Cyp7a1 (also increased in NOD1 KO CHD-fed mice) and Cyp27a1 were significantly increased in NOD1 KO HFD fed mice, compatible with an increase in BA synthesis in NOD1 KO liver (Fig. 5b), due to the elevated levels of cholesterol under these conditions. Here, CYP27A1 is linked to coronary artery disorder.