These metabolic differences included a substantial decrease in Resting Energy Expenditure (REE) during darkness and in lesser motion in HFD NOD1 KO animals, a situation opposite to that observed under CHD (Fig. 2b, and Supplementary Fig. S2), suggesting a role for thyroid hormones (a key player in REE) in this differential response44. This evidence concerns the gene TG and coronary artery disorder.