PNPLA3 and hypothyroidism: The phospholipase Pnpla3 (patatin-like phospholipase domain-containing protein 3; Pnpla3), which is upregulated by T3 and mediates the hydrolysis of triglycerides in adipocytes playing a role on lipid storage homeostasis45,46, was decreased in NOD1 KO adipose tissue from CHD and HFD mice, a situation compatible with hypothyroidism.