Specific dietary effects on the intestinal ecosystem of NOD1 KO mice (not detected in WT mice under HF feeding), such as reductions in Oscillospira, Coprococcus or Streptococcus and increases in others (Dorea, [Ruminococcus] or Bacteroides) could account for the stronger adverse impact of the diet on lipid absorption and metabolism than in WT mice. Here, NOD1 is linked to hydrops fetalis.