Moreover, GO and KEGG enrichment analysis reveals TTFields regulated chaperone-mediated protein folding (CLU, DNAJB4, HSPA1A, HSPA1B, and HSPA6), protein oligomerization (CLU, CRYAB MMP1, and MMP3), rheumatoid arthritis (ANGPT1, CXCL8, MMP1, and MMP3), ATP biosynthetic process (DDIT4, FLCN, and NUPR1), and regulation of microtubule polymerization, mitotic spindle assembly, inclusion body assembly. The gene discussed is HSPA1B; the disease is rheumatoid arthritis.