Moreover, GO and KEGG enrichment analysis reveals TTFields regulated chaperone-mediated protein folding (CLU, DNAJB4, HSPA1A, HSPA1B, and HSPA6), protein oligomerization (CLU, CRYAB MMP1, and MMP3), rheumatoid arthritis (ANGPT1, CXCL8, MMP1, and MMP3), ATP biosynthetic process (DDIT4, FLCN, and NUPR1), and regulation of microtubule polymerization, mitotic spindle assembly, inclusion body assembly. Here, NUPR1 is linked to rheumatoid arthritis.