Conversely, knock down of Nedd4l in the mPFC decreased the degradation of NRG1 and rescued the behavioural changes in CSDS-induced depression-like behaviours, which strongly support that the expression of Nedd4l in the mPFC neurons is required for NRG1 deficiency-mediated susceptibility to stress. The gene discussed is NRG1; the disease is major depressive disorder.