Although the impact of neurodegenerative diseases on cardiac homeostasis remains debatable,1,3 data from our study suggest overt cardiac remodeling (atrophy) and contractile dysfunction in our APP/PS1 mutant model of AD, which is consistent with clinical observations.1,3,5 Similar to previous reports from human4 and experimental models,13,54,55 our present data demonstrated cardiac dysfunction in AD patients and APP/PS1 mice. This evidence concerns the gene PSEN1 and neurodegenerative disease.