PSEN1 and Alzheimer disease: Although ALDH2 ablation itself did not alter mtDNA and cGAS-STING-TBK1 signaling at either basal conditions or in the context of APP/PS1 mutation, it abrogated the melatonin-mediated changes in cytosolic accumulation of mtDNA or cGAS-STING-TBK1 signaling in the APP/PS1 murine model of AD (Fig. 7k–o).