IGFBP3 and nasopharyngeal carcinoma: In summary, we found that circRNA hsa-circ-0046263, which was upregulated in NPC tissues and NPC cell lines, could sponge miR-133a-5p, upregulated the expression of downstream targets gene IGFBP3, and promoted NPC cell migration, invasion, and tumor metastasis (Fig. 7f).