As expected, targeting caspase-1 by Ac-YVAD-cmk substantially reduced the number of pyroptotic cells and live cells expressing caspase-1 in all microglia population (CD45low CD11b+ and CD45int CD11b+) as well as in the CD45int CD11b+ population after cardiac arrest (Fig. 9a, b). The gene discussed is CASP1; the disease is cardiac arrest.