In 2011, genome-wide association studies (GWAS) from two independent groups [25, 26] reported a number of gene variants of nucleotide polymorphisms within SLC14A1 (UT-B gene) on chromosome 18q12.3, are associated with risk of developing UBC in humans, suggesting the possible tumor suppressor role of UT-B in UBC. Here, SLC14A1 is linked to neoplasm.