TNF and neoplasm: Of these proteins, IGF1 (IGF1_HUMAN) is principally interacting with INSR (facilitates the action of insulin), FOXO1 (metabolic regulation under stress conditions), STAT3 (involved in signal transduction and cellular reactions to interleukins) PK3CA (initiates cascades of cell growth, motility, survival and proliferation pathways), AKT1 (regulates cell cycle, angiogenesis and metabolic processes), TNFA (anti-tumor activities and cell differentiation), SOCS3 (negatively regulates cytokine signaling) and IL-6 (immune components differentiation and critical immune responses).