Thus, under high sucrose administration, C3H-Chr 11NSY mice showed hyperglycemia, impaired insulin secretion, and insulin resistance that were comparable to parental NSY mice, indicating that a gene or genes on Chr 11 of the NSY mice could explain these phenotypes in NSY mice under high sucrose environment (Figs. 1b, 2d, and 3b). This evidence concerns the gene INS and Insulin resistance.