FHIT and gonorrhea: Over 20,000 fusion genes have been identified currently.[13] Historically, karyotypic alterations of parotid PAs have been studied since 1973.[14] An extensive study of 220 PAs found that 50% had normal karyotypes, 25% had 8q12 rearrangements, and 13.2% had 12q13–15 rearrangements.[15] In 1997, Kas et al[1] reported PLAG1–CTNNB1 fusion as a critical event in the tumorigenesis of PA and CHCHD7,[2] LIFR,[16] and TCEA1[2,4] as fusion partners of PLAG1. Subsequently, HMGA2-NFIB,[2]HMGA2-FHIT,[3] and HMGA2-WIF1[5] in PAs have also been reported.