The criteria for T2DM diagnosis are high blood glucose (fasting plasma glucose ≥7.0 mmol/L, or 2 h-postprandial plasma glucose ≥11.1 mmol/L during OGTT, or glycosylated hemoglobin ≥6.5%, or random plasma glucose ≥11.1 mmol/L) with normal or elevated insulin levels; the diabetes-related antibodies are usually negative.[9]. The gene discussed is INS; the disease is diabetes mellitus.