NOS3 and type 2 diabetes mellitus: Jafari et al[64] found significant interactions between endothelial nitric oxide synthase (eNOS) G894T and MTHFR C677T in type 2 diabetes, and where both T allele existed, the risk of developing macro-albuminuria was higher (ORMacro = 38.5, 95% CI = 4.7–319).