IL17A and neoplasm: Overexpression of IL-17A and CD70 gene in a collision tumor consisted of primary laryngeal mucosal melanoma and invasive squamous cell carcinoma was reported.[24] Fourthly, carcinogenic risk factors (e.g., smoking and aging) may ultimately trigger in the pathogenesis of multiple primary cancers synchronously.[25] Finally, the synchronous onset of 2 different malignancies in the same site was a random coincidence, which showed no specific relations among these lesions.[13]