Three host proteins are associated with numerous vascular and cardiac phenotypes: LOX with abnormality of blood volume homeostasis, aortic root aneurysm, ascending aortic dissection, carotid artery dilatation, coronary artery atherosclerosis, cystic medial necrosis of the aorta, descending thoracic aorta aneurysm, dilatation of the cerebral artery, left ventricular failure, peripheral arterial stenosis, MYL4 with paroxysmal atrial fibrillation and bradycardia, and SIL1 with abnormal aldolase level. The gene discussed is MYL4; the disease is Aortic root aneurysm.