UBC and viral infectious disease: Further investigations conclusively showed that this interaction is responsible for activating cellular innate immunity to virus infections:26 OASL enhances antiviral signalling mediated by the viral RNA sensor RIG-I by binding through its C-terminal ubiquitin-like domain.26 Other high-impact results from interactome analysis include shared PPIs explaining inverse epidemiological relationship between schizophrenia and rheumatoid arthritis27 and cilia-transduced cell signaling in congenital heart disease,28,29 and more.30