PML (promyelocytic leukaemia bodies are nuclear sub-compartments that repress viral replication through entrapment or epigenetic silencing of the viral genomes.43 Components of PML bodies activate interferon-stimulated genes and cytokines, and may also be upregulated on induction of interferons.43 Therefore, it is conceivable that viruses target PPIs in these structures to circumvent anti-viral defences of the host cell. The gene discussed is PML; the disease is acute promyelocytic leukemia.