To assess mechanisms using circulating biomarkers of cardiac injury [troponin I, N-terminal probrain natriuretic peptide (NT-proBNP)], inflammation [C-reactive protein (CRP)], vascular injury [sACE2, von Willebrand factor (vWF), and interleukin-6 (IL-6)], and thrombotic microangiopathy, and their changes over time. This evidence concerns the gene IL6 and Genetic thrombotic microangiopathy.