Out of 10 associated variants of the MUC4 gene that have been linked to familial GC in Table 2, a heterozygote rs774527434 SNP was identified in one (0.17%) patient among 295 stomach adenocarcinoma germline samples (online S4 Table), approximately 4 times higher than that in the general population (0.04%, Table 2). The gene discussed is MUC4; the disease is gastric adenocarcinoma.