Previously, “silent” nociceptive afferents were proposed to innervate deep body structures,12,27,30 and recently, a potential mechanism for the “unsilencing” of silent nociceptors by NGF-TrkA-Piezo2 was proposed.27 Considering our observed increase in the number of responders in cancer conditions, as well as the fact that the CIBP is NGF-dependent,1,34 it is reasonable to predict that silent nociceptors could significantly contribute to the development of pain in the CIBP rats. The gene discussed is PIEZO2; the disease is cancer.