BPGM, PGAM2, PSPH, and ACOT7 were upregulated in HCC, while AGXT, AGXT2, CBS, CTH, DAO, PGAM1, PGAM4, SHMT1, and SHMT2 were downregulated in HCC (Figure 4F). The gene discussed is SHMT2; the disease is hepatocellular carcinoma.