However, the numbers of methylated CG sites in HIST1H4E and ZFP28 were not different between tumor and normal tissues (1.69 ± 1.43 vs. 1.74 ± 1.70, P=0.587 and 1.69 ± 1.37 vs. 1.47 ± 1.35, P=0.73; Figure 5C,D). The gene discussed is ZFP28; the disease is neoplasm.