Another study showed both lymphocytes and neutrophils response impaired by ethanol consumption in a model of cutaneous infection by Staphylococcus aureus, in which chronic ethanol-fed mice showed great skin lesions and bacteremia associated with reduced IL-17 and IL-1β production, suggesting that Th17-mediated neutrophilic response was impaired (Parlet et al., 2015). The gene discussed is IL1B; the disease is bacterial infectious disease with sepsis.