CXCR2 and Sepsis: It has been well established that the decrease of CXCR2 expression impairs neutrophil migration (Russo et al., 2009), especially in sepsis (Rios-Santos et al., 2007; Alves-Filho et al., 2009), in which a great amount of inflammatory cytokines and chemokines is released to the blood, causing a complex systemic inflammation (Pierrakos and Vincent, 2010).