Here, we noticed that TOX has significant interactions with multiple key genes of exhausted T cell comprising PD‐1 (Cor = .11, P = .014), TIM‐3 (Cor = .18, P < .0001), TIGHT (Cor = .2, P < .0001) and CXCL13 (Cor = .16, P < .001), which play critical role on current cancer immunotherapy. Here, TOX is linked to cancer.