Likewise, lower TOX expression correlates with poor prognosis in lung cancer (OS: P = 1.5e‐05, HR = 0.75 [0.66‐0.86]; PFS: P = .02, HR = 0.8 [0.66‐0.96]), while further subtypes analysis reveals that significant difference only shows in LUAD (OS: P = 5.3e‐05, HR = 0.61 [0.48‐0.78]; PFS: P = 4.4e‐4, HR = 0.57 [0.41‐0.78]) but not in lung squamous cell carcinoma (OS: P = .57, HR = 0.93 [0.73‐1.19]; PFS: P = .26, HR = 0.74 [0.45‐1.24]) (Figure 2A‐C). The gene discussed is TOX; the disease is squamous cell lung carcinoma.