Additionally, the over-activation of AKT kinase signaling pathway plays a key role in resistance of hepatocellular carcinoma, which is either indirectly through the activation of intersecting oncogenic pathways or directly through PI3 kinase, somatic mutation of PTEN, or AKT itself, finally boost tumor survival, growth, and progression [24–26]. The gene discussed is AKT1; the disease is neoplasm.