For example, HOTAIR promotes osteosarcoma development by sponging miR-217 and targeting ZEB1, HOTAIR faciliates gastric cancer progression via miR-217-GPC5 axis, and HOTAIR regulates the development of non-small cell lung cancer through miR-217/DACH1 signaling pathway [20–23]. This evidence concerns the gene HOTAIR and non-small cell lung carcinoma.