The aim of this study is to investigate the methylation patterns of PTPRG gene in a cohort of CML patients in Qatar where resistance to IM treatment has been reported to be significantly higher than other parts of the world (Al‐Dewik, Jewell, Yassin, El‐Ayoubi, & Morsi, 2014). Here, PTPRG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.