Of these, protein tyrosine phosphatase receptor gamma (PTPRG) was described as a tumor suppressor gene in several tumors and its expression level was found to be significantly downregulated in CML patients and correlates with its promoter methylation in both patients and cell lines (Della Peruta, 2010; Tomasello et al., 2020). The gene discussed is PTPRG; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.