PTPRG and chronic myelogenous leukemia, BCR-ABL1 positive: More recently, we demonstrated that in PTPRG‐negative CML cell lines, the methylating enzyme DNA (cytosine‐5)‐methyl transferees 1 (DNMT1) is over‐expressed, bind to PTPRG promoter and is responsible for its hypermethylation, while its inhibition or downregulation correlates with PTPRG re‐expression (Tomasello et al., 2020).