The primary neuropathological signs of AD, including the extracellular deposition of amyloid‐β (Aβ) peptides and intracellular neurofibrillary tau tangles, are closely associated with synapse and neuron loss, ultimately memory impairment in AD (De Strooper & Karran, 2016; Palop & Mucke, 2016; Zott, Busche, Sperling, & Konnerth, 2018). The gene discussed is MAPT; the disease is Alzheimer disease.